Search results for "Release mechanism"

showing 2 items of 2 documents

Liposomes as nonspecific nanocarriers for 5-Fluorouracil in the presence of cyclodextrins

2021

Abstract 5-Fluorouracil (5-FU) is one of anticancer drugs with broad activity. Due to its severe side effects, recent studies concentrate on new ways of directed 5-FU delivery and its release in ill tissue. One of selective carriers could be cyclodextrins and liposomes. The combination of novel methods, leading to formation of inclusion complexes (IC) between host molecule of β-cyclodextrin (β-CD) or 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and 5-FU guest and its subsequent encapsulation in dipalmitoylphosphatidylcholine (DPPC) liposomes is studied experimentally in the present work. Several methods are applied to proof the encapsulation of the analysed drug and its release over time at 37 …

Release mechanismLiposomeCyclodextrins5-Fluorouraciltechnology industry and agricultureCondensed Matter PhysicsCombinatorial chemistryAtomic and Molecular Physics and OpticsFluorescence spectroscopyElectronic Optical and Magnetic MaterialsNMR spectra databasechemistry.chemical_compoundDifferential scanning calorimetrychemistryDipalmitoylphosphatidylcholineLiposomesMaterials ChemistryProton NMRMoleculelipids (amino acids peptides and proteins)Physical and Theoretical ChemistryNanocarriersSpectroscopyControlled drug deliveryJournal of Molecular Liquids
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The Advances and Challenges of Liposome-Assisted Drug Release in the Presence of Serum Albumin Molecules: The Influence of Surrounding pH

2022

The aim of this study is to prepare a liposomal delivery system for 5-methyl-12 (H)-quino[3,4-b]-1,4-benzothiazine chloride (5-MBT) and study the in vitro release characteristics. The release of 5-MBT from a liposomal complex with human serum albumin (HSA) [LDPPC/5-MBT]:HSA was examined using the spectrophotometric method and differential scanning calorimetry (DSC). Electronic paramagnetic resonance was used to assess the influence of the pH of the environment on the conformation of phospholipids, the latter determining the degree of release of the encapsulated compound. The applied mathematical models made it possible to determine the necessary analytical parameters to facilitate the proce…

biological systems; release mechanism; controlled drug delivery; nanoparticlesrelease mechanismembryonic structuresbiological systemsnanoparticlesGeneral Materials Sciencecontrolled drug deliveryMaterials
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